Missouri might be known for the Gateway Arch and deep BBQ roots, but if you’ve never twisted the throttle through its rolling hills, riverfronts, and forested stretches—you’re missing out on some top-tier riding. The state is packed with both well-loved motorcycle routes and lesser-known gems that offer sweeping views, surprising elevation changes, and old-school charm. Whether you’re on two wheels or, like me these days, enjoying the stability of three wheels thanks to my Can-Am Spyder RT, Missouri serves up ride-after-ride full of that soul-cleansing wind therapy.

From the Ozarks to the bluffs along the Mississippi, the rides here are like that perfect playlist: a little bluesy, a little wild, and just what you need to feel alive again. And if you're anything like me—a Gen X dirt-bike girl turned motorcycle mom who still needs her dose of adrenaline—you’ll find Missouri has just the right mix of scenery, curves, and hidden eats to make your ride memorable.

Scenic Missouri Motorcycle Routes Worth the Ride

Ozark Hellbender Route (MO-19 & MO-106 Loop)

The name alone is enough to grab your attention. The Ozark Hellbender isn’t just a cool-sounding ride—it’s a full-on immersion into dense forest, bluff lines, and those beautiful backcountry curves that Missouri does so well.

You’ll start near Eminence, Missouri, a town that feels like it’s been marinating in Americana for decades. From there, head south on MO-19, swing east on MO-106, and you’ll find yourself zigzagging through Mark Twain National Forest. Elevation changes here are legit—not quite Rocky Mountain-worthy, but enough to keep your attention if your reflexes are a little too relaxed after breakfast.

Where to Eat:
Riverside Grill in Eminence is a local favorite—casual, tasty, and right along the Jacks Fork River. Grab the catfish platter and thank me later.

Where to Stay:
Shady Lane Cabins & Motel offers that perfect mix of rustic and comfort. Plenty of parking for bikes and right in the middle of everything.

Missouri Wine Country Ride (MO-94 & MO-100)

For those looking to pair scenic riding with a splash of Merlot, Missouri Wine Country is calling. The ride along MO-94 and MO-100 traces the Missouri River and feels like someone paved a road just for motorcyclists who like their routes scenic, smooth, and stocked with roadside surprises.

Start your journey near St. Charles, head west on MO-94 through Defiance, Augusta, and into Washington. Then hop onto MO-100, a favorite stretch for sport and touring bikes alike. This area is especially beautiful in fall, with trees throwing down colors like confetti at a homecoming parade.

Where to Eat:
The Silly Goose in Augusta delivers artisan-level sandwiches and laid-back biker-friendly vibes. If you roll into Washington, stop at Old Dutch Tavern for bratwursts and ice-cold beer that doesn’t taste like it came from a vending machine.

Where to Stay:
River Sirens Hotel in Washington has that boutique charm, views of the river, and plenty of food and drinks within walking distance.

The Glade Top Trail Scenic Byway

Want something quieter? Something that reminds you of how Missouri used to feel before everything was a little too connected and a little too busy? The Glade Top Trail down in Southwest Missouri near Ava is it.

It’s technically a gravel-based National Forest Scenic Byway, but don’t let that scare you—especially if you’re on an adventure bike or three-wheeler like I am now. It’s 23 miles of breathtaking ridgeline riding through the Mark Twain National Forest, with panoramic views that will stop you mid-sentence (or mid-curse, depending on your comfort level with gravel).

Where to Eat:
True Brew Coffee & Cafe in Ava is a gem—fresh pastries, killer breakfast burritos, and service with a smile that doesn’t feel forced.

Where to Stay:
Skip the chain motels and go with something more peaceful and authentic. Check out highly rated Airbnb options in the Ava area, like “Cabin in the Woods – Secluded Getaway near Ava”. You’ll find quiet, private cabins with fire pits, scenic porches, and room to park your bike right outside. Bonus: Most of them are hosted by locals who actually appreciate riders coming through.

If you’re looping through the region and don’t mind a slightly longer ride, Pinewood Cabins in Eminence also offers well-kept, rider-friendly lodging that blends comfort with rustic charm.

Hidden Gems for the Two-Wheeled Soul

Route 66 – Missouri Stretch

You can’t ride Missouri without putting some miles on the original Route 66. It winds its nostalgic way from St. Louis to Joplin, and there’s something deeply satisfying about cruising the “Mother Road” on a steel horse.

From the old-school gas stations to the neon signs and diners that still serve chocolate malts the way they did in the '50s, this is more than a ride—it’s a time machine. While much of it has been bypassed by the interstate, the preserved stretches offer a riding rhythm that’s just the right kind of slow.

Where to Eat:
The Cuba Bakery & Deli in Cuba, Missouri (nicknamed “Route 66 Mural City”) makes one heck of a Cuban sandwich. In Lebanon, don’t miss Elm Street Eatery—comfort food that sticks with you, just like Grandma's guilt trips.

Where to Stay:
Wagon Wheel Motel in Cuba is a Route 66 landmark. It’s not just a place to sleep—it’s part of the ride.

Breathtaking Parks Along the Way

Elephant Rocks State Park

If you're near Ironton, swing into Elephant Rocks State Park. It’s not a long detour, but it's worth it. Giant boulders form a natural playground, and the loop road to get there from MO-21 is both smooth and scenic.

Ha Ha Tonka State Park

Don’t let the goofy name fool you—Ha Ha Tonka is a stunning place to park the bike and stretch your legs. Located near Lake of the Ozarks, the park features castle ruins, caves, sinkholes, and killer lake views. The ride in on MO-D and MO-54 is pure joy—twisties, elevation, and just enough turns to make you feel alive without making you feel old.

Pro Tips from a Three-Wheel Convert

As someone who went from sport-touring on two wheels to exploring Missouri from the saddle of a Can-Am Spyder RT, I’ll say this: Missouri roads are tailor-made for trikes. The curves are friendly, the pavement’s generally decent (Missouri winters aside), and the towns along the way seem to appreciate riders. That matters when you’re rolling into a diner at 10 a.m. in full gear, looking like a sweaty stormtrooper.

Also, don’t overplan. Some of the best parts of Missouri are the roads that weren’t even on your route but called your name anyway. Those little unexpected detours? That’s the good stuff.